CLONING AND SEQUENCE-ANALYSIS OF A CDNA-ENCODING A PRECURSOR FOR RAT C-TYPE NATRIURETIC PEPTIDE (CNP)

被引：201

作者：

KOJIMA, M

MINAMINO, N

KANGAWA, K

MATSUO, H

机构：

[1] NATL CARDIOVASC CTR,FUJISHIRODAI,SUITA,OSAKA 565,JAPAN

[2] MIYAZAKI MED COLL,DEPT BIOCHEM,MIYAZAKI 88916,JAPAN

来源：

FEBS LETTERS | 1990年 / 276卷 / 1-2期

关键词：

C-TYPE NATRIURETIC PEPTIDE; CDNA CLONING; PRECURSOR STRUCTURE; A-TYPE NATRIURETIC PEPTIDE; B-TYPE NATRIURETIC PEPTIDE; NEUROPEPTIDE;

D O I：

10.1016/0014-5793(90)80544-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent identification of a C-type natriuretic peptide (CNP) in porcine brain strongly suggested that a third member of the natriuretic peptide family still remains to be identified in other species of mammals. A cDNA encoding a precursor for rat CNP was cloned from a rat brain cDNA library and sequenced. The precursor was a 126-residue peptide, carrying a 23-residue signal sequence at the N-terminus and the known porcine CNP-53 sequence at the C-terminus. By RNA blot analysis, rat CNP mRNA was found to be expressed exclusively in the brain, implying that CNP may function in the central nervous system as a neuropeptide.

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页码：209 / 213

页数：5

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