INDUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA MESSENGER-RNA IN THE BRAIN AFTER PERIPHERAL ENDOTOXIN TREATMENT - COMPARISON WITH INTERLEUKIN-1 FAMILY AND INTERLEUKIN-6

被引：242

作者：

GATTI, S

BARTFAI, T

机构：

[1] UNIV STOCKHOLM, DEPT NEUROCHEM & NEUROTOXICOL, SVANTE ARRHENIUS VAG 21A, S-10691 STOCKHOLM, SWEDEN

[2] MARIO NEGRI INST PHARMACOL RES, NEUROIMMUNOL LAB, I-20157 MILAN, ITALY

来源：

BRAIN RESEARCH | 1993年 / 624卷 / 1-2期

关键词：

TUMOR NECROSIS FACTOR; INTERLEUKIN-1; INTERLEUKIN-6; INTERLEUKIN-1 RECEPTOR ANTAGONIST; ENDOTOXIN; BRAIN; RAT;

D O I：

10.1016/0006-8993(93)90090-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The constitutive expression of tumor necrosis factor-alpha (TNFalpha) mRNA and its induction (60 min later) by peripheral injection of Escherichia coli lipopolysaccharide (2 mg/kg i.p.) was demonstrated by polymerase chain reaction (PCR), in the pituitary and hypothalamus but not in the striatum or hippocampus of the rat. The pattern of TNFalpha mRNA induction is different from that observed for mRNAs of IL-1alpha and IL-1beta, IL-1ra and IL-6 respectively. This demonstration of the induction of TNFalpha in the brain may contribute to our understanding of the central effects of TNFalpha in fever and anorexia.

引用

页码：291 / 294

页数：4

共 17 条

[1] BRAIN INTERLEUKIN-1 GENE-EXPRESSION INDUCED BY PERIPHERAL LIPOPOLYSACCHARIDE ADMINISTRATION [J].