REDUCTION OF INFARCT VOLUME BY MAGNESIUM AFTER MIDDLE CEREBRAL-ARTERY OCCLUSION IN RATS

被引：147

作者：

IZUMI, Y ^{[1
]}

ROUSSEL, S ^{[1
]}

PINARD, E ^{[1
]}

SEYLAZ, J ^{[1
]}

机构：

[1] UNIV PARIS 07,RECH CEREBROVASC LAB,CNRS,UA 641,10 AVE VERDUN,F-75010 PARIS,FRANCE

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1991年 / 11卷 / 06期

关键词：

D O I：

10.1038/jcbfm.1991.170

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of magnesium, an endogenous inhibitor of calcium entry into neurons, upon ischemic brain damage were investigated using a well-characterized model of focal cerebral ischemia in rats. Infarct volumes were determined by 2,3,5-triphenyltetrazolium chloride transcardiac perfusion 48 h after middle cerebral artery (MCA) occlusion. The area of ischemic damage was quantified by image analysis in coronal sections taken every 0.5 mm. MgCl2 (1 mmol/kg) was injected intraperitoneally just after MCA occlusion and again 1 h later. Posttreatment with MgCl2 (16 control and 16 treated rats) significantly reduced the cortical infarct volume. Compensation for the hyperglycemic effect of MgCl2 with insulin (17 rats) further reduced the infarct volume in the neocortex. No systemic effects of either treatment could account for the observed neuroprotection.

引用

页码：1025 / 1030

页数：6

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