REACTIVE OXYGEN SPECIES AND AIRWAY INFLAMMATION

被引：438

作者：

BARNES, PJ

机构：

[1] Department of Thoracic Medicine, National Heart and Lung Institute, London

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 9卷 / 03期

关键词：

Airway epithelium; Asthma; Bronchoconstriction; Eosinophil; Free radicals; Macrophage; Mast cell;

D O I：

10.1016/0891-5849(90)90034-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species may be generated by several inflammatory cells which participate in airway inflammation and their production may be increased in asthma. Oxygen metabolites may contribute to the epithelial damage which is characteristic of asthmatic airways and may activate cells such as mast cells in the airway mucosa. Reactive oxygen species may cause bronchoconstriction, mucus secretion, have effect on airway vasculature, and may increase airway responsiveness. The role of reactive that antioxidant defenses may be defective in asthma. If reactive oxygen species participate in the inflammatory response in airway disease, then radical scavengers or antioxidants could play a useful role in therapy. © 1990.

引用

页码：235 / 243

页数：9

共 80 条

[1]

Brigham, Role of free radicals in lung injury, Chest, 89, pp. 859-863, (1986)

[2]

Baldwin, Simon, Grum, Ketai, Boxer, Devall, Oxidant activity in expired breath of patients with adult respiratory distress syndrome, Lancet, 1, pp. 11-14, (1986)

[3]

Barnes, New concepts in the pathogenesis of bronchial hyperresponsiveness and asthma, J. Allergy Clin. Immunol., 83, pp. 1013-1026, (1989)

[4]

Barnes, A new approach to asthma therapy, N. Engl. J. Med., 321, pp. 1517-1527, (1989)

[5]

Dunnill, The pathology of asthma with special reference to changes in the bronchial mucosa, J. Clin. Path., 13, pp. 27-33, (1960)

[6]

Laitinen, Heino, Laitinen, Kava, Haahtela, Damage of the airway epithelium and bronchial reactivity in patients with asthma, Am. Rev. Respir. Dis., 131, pp. 599-606, (1985)

[7]

Beasley, Roche, Roberts, Holgate, Cellular events in the bronchial in mild asthma and after bronchial provocation, Am. Rev. Respir. Dis., 139, pp. 806-817, (1989)

[8]

Barnes, Chung, Page, Inflammatory mediators in asthma, Pharmacol. Rev., 40, pp. 49-84, (1988)

[9]

Drath, Karnovsky, Superoxide production by phagocytic leukocytes, J. Exp. Med., 141, pp. 257-262, (1975)

[10]

Babior, The respiratory burst of phagocytes, J. Clin. Invest., 73, pp. 599-601, (1984)

← 1 2 3 4 5 6 7 8 →