RACEMIZED D-ASPARTATE IN ALZHEIMER NEUROFIBRILLARY TANGLES

被引：37

作者：

FISHER, GH

PAYAN, IL

CHOU, SJ

MAN, EH

CERWINSKI, S

MARTIN, T

EMORY, C

FREY, WH

机构：

[1] UNIV MIAMI,DEPT CHEM,CORAL GABLES,FL 33124

[2] ST PAUL RAMSEY MED CTR,RAMSEY CLIN,CTR ALZHEIMERS TREATMENT & RES,ST PAUL,MN 55101

来源：

BRAIN RESEARCH BULLETIN | 1992年 / 28卷 / 01期

关键词：

D-ASPARTATE; D-ASP; ALZHEIMERS DISEASE; NEUROFIBRILLARY TANGLES; HUMAN BRAIN;

D O I：

10.1016/0361-9230(92)90239-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Normal protein-bound L-aspartyl/L-asparaginyl residues may undergo posttranslational modification by racemization to D-aspartate. Based on preliminary results reported here, proteins associated with Alzheimer neurofibrillary tangle preparations contain a greater number of these racemized D-aspartyl residues than the unaffected proteins from the surrounding gray matter or in comparable preparations from normal brains.

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页码：127 / 131

页数：5

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