REACTION OF NO WITH O-2- IMPLICATIONS FOR THE ACTION OF ENDOTHELIUM-DERIVED RELAXING FACTOR (EDRF)

被引：258

作者：

SARAN, M

MICHEL, C

BORS, W

机构：

[1] Institut für Strahlenbiologie, GSF Research Center

来源：

FREE RADICAL RESEARCH COMMUNICATIONS | 1990年 / 10卷 / 4-5期

关键词：

Biological messenging; Endothelial derived relaxation factor; Nitric oxide; Peroxonitrite; Superoxide anion;

D O I：

10.3109/10715769009149890

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Under physiological pH conditions (pH 7.2-7.4) the rate constant of the reaction NO + O2 yielding peroxonitrite (ONOO) was determined as k = (3.7 ± 1.1) × 107 M 1 s 1. The decay of peroxonitrite at this pH follows first order kinetics with a rate constant of 1.4 s 1. At alkaline pH peroxonitrite is practically stable. Possible consequences of these reactions for the biological lifetime of EDRF will be discussed. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：221 / 226

页数：6

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