G-PROTEINS

被引：898

作者：

HEPLER, JR

GILMAN, AG

机构：

[1] Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75235

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 10期

关键词：

D O I：

10.1016/0968-0004(92)90005-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The family of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) serves an essential role in transducing receptor-generated signals across the plasma membrane. Recent findings reveal unexpected functional roles for individual G protein subunits. Thus, GTP-binding alpha-subunits and the betagamma-subunit complex can influence the activity of effector molecules independently or simultaneously, either synergistically or in opposition, to elicit a complex constellation of cellular events.

引用

页码：383 / 387

页数：5

共 31 条

[1]

BLUMER KJ, 1991, ANNU REV PHYSIOL, V53, P37

[2]

BOURNE HR, 1991, NATURE, V349, P117, DOI 10.1038/349117a0

[3] THE GTPASE SUPERFAMILY - A CONSERVED SWITCH FOR DIVERSE CELL FUNCTIONS [J].