CLONING AND SEQUENCING OF A FULL LENGTH CDNA CODING FOR A HUMAN APOFERRITIN H-CHAIN - EVIDENCE FOR A MULTIGENE FAMILY

被引：92

作者：

COSTANZO, F ^{[1
]}

SANTORO, C ^{[1
]}

COLANTUONI, V ^{[1
]}

BENSI, G ^{[1
]}

RAUGEI, G ^{[1
]}

ROMANO, V ^{[1
]}

CORTESE, R ^{[1
]}

机构：

[1] EUROPEAN MOLEC BIOL LAB, MEYERHOFSTR 1, D-6900 HEIDELBERG, FED REP GER

来源：

EMBO JOURNAL | 1984年 / 3卷 / 01期

关键词：

D O I：

10.1002/j.1460-2075.1984.tb01756.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A segment of c[complementary]DNA from human liver coding for an apoferritin subunit, probably an H chain. Sequence comparison with the available protein sequence shows that the clone corresponds to a ferritin subunit present as a minor species in human spleen and placenta, but as major species in HeLa cells. Northern blot analysis shows the existence of only 1 band of similar size in human liver, HeLa cells, Daudi lymphoma and Hep3B hepatoma cell lines. In contrast, Southern blot analysis provides evidence for a multigene family.

引用

页码：23 / 27

页数：5

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