RIBONUCLEASE MIMICS

被引：63

作者：

BRESLOW, R

ANSLYN, E

HUANG, DL

机构：

[1] Department of Chemistry, Columbia University New York

来源：

TETRAHEDRON | 1991年 / 47卷 / 14-15期

关键词：

D O I：

10.1016/S0040-4020(01)81774-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cleavage of the ribonucleotide UpU by imidazole buffers shows kinetic behavior that indicates a sequential bifunctional mechanism, in which the imidazolium ion acts first. Similar results are obtained for the cleavage of ApA. This mechanism is related to the simultaneous bifunctional cleavage of RNA by the enzyme ribonuclease, and has guided us to the synthesis of an improved cyclodextrin-bis-imidazole enzyme mimic that also uses a simultaneous bifunctional mechanism.

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页码：2365 / 2376

页数：12

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