CHEMOSENSORY NEURONS WITH OVERLAPPING FUNCTIONS DIRECT CHEMOTAXIS TO MULTIPLE CHEMICALS IN C-ELEGANS

被引:556
作者
BARGMANN, CI [1 ]
HORVITZ, HR [1 ]
机构
[1] MIT,DEPT BIOL,HOWARD HUGHES MED INST,CAMBRIDGE,MA 02139
关键词
D O I
10.1016/0896-6273(91)90276-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The functions of the 11 classes of exposed chemosensory neurons of C. elegans were tested by killing cells with a laser microbeam. One pair of neurons, the ASE neurons, is uniquely important for chemotaxis: killing the ASE neurons greatly reduced chemotaxis to cAMP, biotin, Cl-, and Na+. Additional chemosensory function is distributed among several other cell types. Thus, 3 pairs of chemosensory neurons (ADF, ASG, and ASI) contribute to a residual response to cAMP, biotin, Cl-, and Na+ after ASE is killed. Chemotaxis to lysine similarly depends on the partly redundant functions of 4 pairs of chemosensory neurons (ASE, ASG, ASI, and ASK). The combined activity of several neuron types that act in parallel might increase the fidelity of chemotaxis.
引用
收藏
页码:729 / 742
页数:14
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