POSSIBLE INVOLVEMENT OF NITRIC-OXIDE IN LONG-TERM POTENTIATION

被引：625

作者：

BOHME, GA

BON, C

STUTZMANN, JM

DOBLE, A

BLANCHARD, JC

机构：

[1] Rhône-Poulenc Rorer, Centre de Recherches de Vitry-Alfortville, Vitry-sur-Seine

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 199卷 / 03期

关键词：

NITRIC OXIDE (NO); LONG-TERM POTENTIATION; HIPPOCAMPUS (RAT); SYNAPTIC PLASTICITY;

D O I：

10.1016/0014-2999(91)90505-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Long-term potentiation (LTP) in the hippocampus is known to involve NMDA (N-methyl-D-aspartate) receptors. Since activation of NMDA receptors in the cerebellum results in the formation of nitric oxide (NO), we studied the possible involvement of this messenger in hippocampal synaptic plasticity. We report here that the NO-synthase inhibitor, L-N-omega-nitroarginine, blocks LTP and that sodium nitroprusside, which releases NO, produces a long-lasting enhancement in synaptic efficacy which is not additive with tetanus-induced LTP.

引用

收藏

页码：379 / 381

页数：3

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