FISSION YEAST CDC25 IS A CELL-CYCLE REGULATED PROTEIN

被引：67

作者：

DUCOMMUN, B

DRAETTA, G

YOUNG, P

BEACH, D

机构：

[1] Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 167卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91765-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fission yeast cell division is initiated by the cdc2 cdc13-cyclin protein kinase which in its catalytically active state comprises the mitotic inducer. During interphase the cdc2/cyclin complex is assembled in an inactive state that requires cdc25+ gene function for M-phase activation. The cdc25+ product, a 76 kd phosphoprotein, is shown to oscillate in abundance during the cell cycle, reaching a peak at G2 M, and to be sensitive to nitrogen starvation. The level of cdc25 is subject to feedback regulation involving both cdc25 and cdc2. © 1990.

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页码：301 / 309

页数：9

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