RNA-POLYMERASE - STRUCTURAL DETERMINANT OF THE CHROMATIN LOOP AND THE CHROMOSOME

被引：51

作者：

COOK, PR

机构：

[1] CRC Nuclear Structure and Function Research Group, Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, South Parks Road

来源：

BIOESSAYS | 1994年 / 16卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1002/bies.950160611

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Current models for RNA synthesis involve an RNA polymerase that tracks along a static template. However, research on chromatin loops suggests that the template slides past a stationary polymerase; individual polymerases tie the chromatin fibre into loops and dusters of polymerases determine the basic structure of the interphase and metaphase chromosome. RNA polymerase is then both a player and a manager of the chromosome loop.

引用

页码：425 / 430

页数：6

共 43 条

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