ENDOTHELIN MESSENGER-RNA AND RECEPTORS ARE DIFFERENTIALLY EXPRESSED IN CULTURED HUMAN BREAST EPITHELIAL AND STROMAL CELLS

被引：94

作者：

BALEY, PA ^{[1
]}

RESINK, TJ ^{[1
]}

EPPENBERGER, U ^{[1
]}

HAHN, AWA ^{[1
]}

机构：

[1] BASEL UNIV HOSP,DEPT RES,CH-4031 BASEL,SWITZERLAND

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1990年 / 85卷 / 04期

关键词：

breast tissue; endothelin expression; endothelin receptors;

D O I：

10.1172/JCI114570

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Paracrine regulation is implicit in th biosynthesis and secretion of milk in the breast. An important determinant for this regulation in vivo is proximate cellular location as exemplified by stromal and epithelial cells in breast tissue. Cultured human breast epithelial cells exhibited low constitutive expression of mRNA for endothelin which was enhanced 20-fold after prolactin stimulation. Human breast stromal cells did not express measurable levels of endothelin mRNA under similar conditions. In a similar differential manner, the stimulated release of immunoreactive endothelin into medium overlay was observed only for breast epithelial and not stromal cells. Specific cell-surface receptors for endothelin and biochemical responsiveness to the peptide were observed only in the stromal cells.

引用

页码：1320 / 1323

页数：4

共 13 条

[1] ENDOTHELIN IS A POTENT SECRETAGOGUE FOR ATRIAL NATRIURETIC PEPTIDE IN CULTURED RAT ATRIAL MYOCYTES [J].