A NEWLY FOUND ANGIOTENSIN-II RECEPTOR SUBTYPE MEDIATES CYCLIC-GMP FORMATION IN DIFFERENTIATED NEURO-2A CELLS

被引：39

作者：

CHAKI, S ^{[1
]}

INAGAMI, T ^{[1
]}

机构：

[1] VANDERBILT UNIV,MED CTR,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37232

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 225卷 / 04期

关键词：

ANGIOTENSIN-II RECEPTOR; CGMP; NEURO-2A CELLS;

D O I：

10.1016/0922-4106(92)90111-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In search of the functional role of the newly found angiotensin II (Ang II) binding site which is expressed in differentiated Neuro-2A cells, we found that Ang II causes a marked stimulation of cGMP formation dose-dependently. The stimulation was blocked by the nonselective Ang II receptor antagonist [Sar1,Ile8]Ang II but not by the AT1 antagonist DuP 753 or the AT2 antagonist PD 123319. These results suggest that Ang II increased cGMP level via a new Ang II receptor subtype in differentiated Neuro-2A cells.

引用

页码：355 / 356

页数：2

共 5 条

[1]

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