CENTROMERE - HUB OF CHROMOSOMAL ACTIVITIES

被引：296

作者：

PLUTA, AF ^{[1
]}

MACKAY, AM ^{[1
]}

AINSZTEIN, AM ^{[1
]}

GOLDBERG, IG ^{[1
]}

EARNSHAW, WC ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT CELL BIOL & ANAT, BALTIMORE, MD 21205 USA

来源：

SCIENCE | 1995年 / 270卷 / 5242期

关键词：

D O I：

10.1126/science.270.5242.1591

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Centromeres are the structures that direct eukaryotic chromosome segregation In mitosis and meiosis. There are two major classes of centromeres. Point centromeres, found in the budding yeasts, are compact loci whose constituent proteins are now beginning to yield to biochemical analysis. Regional centromeres, best described in the fission yeast Schizosaccharomyces pombe, encompass many kilobases of DNA and are packaged into heterochromatin. Their associated proteins are as yet poorly understood. In addition to providing the site for microtubule attachment, centromeres also have an important role in checkpoint regulation during mitosis.

引用

页码：1591 / 1594

页数：4

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