AN INFECTIOUS MOLECULAR CLONE OF AN UNUSUAL MACROPHAGE-TROPIC AND HIGHLY CYTOPATHIC STRAIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1

被引：340

作者：

COLLMAN, R

BALLIET, JW

GREGORY, SA

FRIEDMAN, H

KOLSON, DL

NATHANSON, N

SRINIVASAN, A

机构：

[1] UNIV PENN,SCH MED,DEPT NEUROL,PHILADELPHIA,PA 19104

[2] UNIV PENN,SCH MED,DEPT MICROBIOL,PHILADELPHIA,PA 19104

[3] UNIV PENN,SCH MED,DEPT MED,DIV INFECT DIS,PHILADELPHIA,PA 19104

[4] WISTAR INST,PHILADELPHIA,PA 19104

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 12期

关键词：

D O I：

10.1128/JVI.66.12.7517-7521.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We isolated and molecularly cloned a human immunodeficiency virus type 1 (HIV-1) strain (89.6) which is unusual because it is both macrophage-tropic and extremely cytopathic in lymphocytes. Moreover, this is the first well-characterized infectious molecularly cloned macrophage-tropic HIV-1 strain derived from peripheral blood. HIV-1 89.6 differs markedly from other macrophage-tropic isolates within the envelope V3 region, which is important in determining cell tropism and cytopathicity. HIV-1 89.6 may thus represent a transitional isolate between noncytopathic macrophage-tropic viruses and cytopathic lymphocyte-tropic viruses.

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页码：7517 / 7521

页数：5

相关论文

共 28 条

[1] THE REGION OF THE ENVELOPE GENE OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RESPONSIBLE FOR DETERMINATION OF CELL TROPISM [J].

CANN, AJ ;

CHURCHER, MJ ;

BOYD, M ;

OBRIEN, W ;

ZHAO, JQ ;

ZACK, J ;

CHEN, ISY .

JOURNAL OF VIROLOGY, 1992, 66 (01) :305-309

[2] ISOLATES OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 FROM THE BRAIN MAY CONSTITUTE A SPECIAL GROUP OF THE AIDS VIRUS [J].

CHENGMAYER, C ;

WEISS, C ;

SETO, D ;

LEVY, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (21) :8575-8579

[3] BIOLOGICAL CHARACTERIZATION OF PAIRED HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 ISOLATES FROM BLOOD AND CEREBROSPINAL-FLUID [J].

CHIODI, F ;

VALENTIN, A ;

KEYS, B ;

SCHWARTZ, S ;

ASJO, B ;

GARTNER, S ;

POPOVIC, M ;

ALBERT, J ;

SUNDQVIST, VA ;

FENYO, EM .

VIROLOGY, 1989, 173 (01) :178-187

[4] INFECTION OF MONOCYTE-DERIVED MACROPHAGES WITH HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) - MONOCYTE-TROPIC AND LYMPHOCYTE-TROPIC STRAINS OF HIV-1 SHOW DISTINCTIVE PATTERNS OF REPLICATION IN A PANEL OF CELL-TYPES [J].

COLLMAN, R ;

HASSAN, NF ;

WALKER, R ;

GODFREY, B ;

CUTILLI, J ;

HASTINGS, JC ;

FRIEDMAN, H ;

DOUGLAS, SD ;

NATHANSON, N .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (04) :1149-1163

[5] PROGRESSIVE SEQUENCE ALIGNMENT AS A PREREQUISITE TO CORRECT PHYLOGENETIC TREES [J].

FENG, DF ;

DOOLITTLE, RF .

JOURNAL OF MOLECULAR EVOLUTION, 1987, 25 (04) :351-360

[6]

FENYO EM, 1988, J VIROL, V62, P4414

[7] PHENOTYPE-ASSOCIATED SEQUENCE VARIATION IN THE 3RD VARIABLE DOMAIN OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GP120 MOLECULE [J].

FOUCHIER, RAM ;

GROENINK, M ;

KOOTSTRA, NA ;

TERSMETTE, M ;

HUISMAN, HG ;

MIEDEMA, F ;

SCHUITEMAKER, H .

JOURNAL OF VIROLOGY, 1992, 66 (05) :3183-3187

[8] CHARACTERIZATION OF THE FUSION DOMAIN OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE GLYCOPROTEIN GP41 [J].

FREED, EO ;

MYERS, DJ ;

RISSER, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) :4650-4654

[9] IDENTIFICATION OF THE ENVELOPE V3 LOOP AS THE PRIMARY DETERMINANT OF CELL TROPISM IN HIV-1 [J].

HWANG, SS ;

BOYLE, TJ ;

LYERLY, HK ;

CULLEN, BR .

SCIENCE, 1991, 253 (5015) :71-74

[10] CONSERVED SEQUENCE AND STRUCTURAL ELEMENTS IN THE HIV-1 PRINCIPAL NEUTRALIZING DETERMINANT [J].

LAROSA, GJ ;

DAVIDE, JP ;

WEINHOLD, K ;

WATERBURY, JA ;

PROFY, AT ;

LEWIS, JA ;

LANGLOIS, AJ ;

DREESMAN, GR ;

BOSWELL, RN ;

SHADDUCK, P ;

HOLLEY, LH ;

KARPLUS, M ;

BOLOGNESI, DP ;

MATTHEWS, TJ ;

EMINI, EA ;

PUTNEY, SD .

SCIENCE, 1990, 249 (4971) :932-935