LEPTIN LEVELS IN HUMAN AND RODENT - MEASUREMENT OF PLASMA LEPTIN AND OB RNA IN OBESE AND WEIGHT-REDUCED SUBJECTS

被引：3173

作者：

MAFFEI, M

HALAAS, J

RAVUSSIN, E

PRATLEY, RE

LEE, GH

ZHANG, Y

FEI, H

KIM, S

LALLONE, R

RANGANATHAN, S

KERN, PA

FRIEDMAN, JM

机构：

[1] ROCKEFELLER UNIV, MOLEC GENET LAB, NEW YORK, NY 10021 USA

[2] NIDDKD, CLIN DIABET & NUTR SECT, PHOENIX, AZ 85016 USA

[3] BROOKWOOD BIOMED ACC, BIRMINGHAM, AL 35209 USA

[4] CEDARS SINAI MED CTR, LOS ANGELES, CA 90048 USA

[5] ROCKEFELLER UNIV, HOWARD HUGHES MED INST, NEW YORK, NY 10021 USA

来源：

NATURE MEDICINE | 1995年 / 1卷 / 11期

关键词：

D O I：

10.1038/nm1195-1155

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leptin, the gene product of the obese gene, may play an important role in regulating body weight by signalling the size of the adipose tissue mass. Plasma leptin was found to be highly correlated with body mass index (BMI) in rodents and in 87 lean and obese humans. In humans, there was variability in plasma leptin at each BMI suggesting that there are differences in its secretion rate from fat. Weight loss due to food restriction was associated with a decrease in plasma leptin in samples from mice and obese humans.

引用

页码：1155 / 1161

页数：7

共 47 条

[1] STRATEGIES OF ANTICYTOKINE MONOCLONAL-ANTIBODY DEVELOPMENT - IMMUNOASSAY OF IL-10 AND IL-5 IN CLINICAL-SAMPLES [J].