MORPHINE ENHANCES THE ACTIVITY OF THERMORECEPTIVE COLD-SPECIFIC LAMINA-I SPINOTHALAMIC NEURONS IN THE CAT

被引：57

作者：

CRAIG, AD ^{[1
]}

HUNSLEY, SJ ^{[1
]}

机构：

[1] BARROW NEUROL INST, DIV NEUROSURG, PHOENIX, AZ 85013 USA

来源：

BRAIN RESEARCH | 1991年 / 558卷 / 01期

关键词：

THERMORECEPTION; THERMOREGULATION; PAIN; ANALGESIA; SPINAL PHYSIOLOGY; OPIATE;

D O I：

10.1016/0006-8993(91)90719-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The possibility that morphine might differentially affect spinal neurons responsive to small-diameter thermoreceptive-specific afferents was tested. Systemic morphine enhanced a portion or all of the stimulus-response function of 7 of 9 lamina I spinothalamic tract cells specifically sensitive to cold applied to the glabrous hindpaw in the cat. This result contrasts strongly with the predominant inhibition of nociceptive lamina I neurons by morphine.

引用

页码：93 / 97

页数：5

共 47 条

[1]

APPELBAUM BD, 1984, J PHARMACOL EXP THER, V231, P555

[2]

AYLIFFE SJ, 1979, J PHYSIOL-LONDON, V293, pP65

[3]

BEHAR M, 1979, LANCET, V1, P527

[4] ANALGESIC EFFECT OF VIBRATION AND COOLING ON PAIN INDUCED BY INTRANEURAL ELECTRICAL-STIMULATION [J].

BINI, G ;

CRUCCU, G ;

HAGBARTH, KE ;

SCHADY, W ;

TOREBJORK, E .

PAIN, 1984, 18 (03) :239-248

[5] EPIDURAL NARCOTICS IN VOLUNTEERS - SENSITIVITY TO PAIN AND TO CARBON-DIOXIDE [J].

BROMAGE, PR ;

CAMPORESI, E ;

LESLIE, J .

PAIN, 1980, 9 (02) :145-160

[6] NEUROCHEMICAL ORGANIZATION OF THE HYPOTHALAMIC PROJECTION TO THE SPINAL-CORD IN THE RAT [J].

CECHETTO, DF ;

SAPER, CB .

JOURNAL OF COMPARATIVE NEUROLOGY, 1988, 272 (04) :579-604

[7] SPINAL NEURONS SPECIFICALLY EXCITED BY NOXIOUS OR THERMAL STIMULI - MARGINAL ZONE OF DORSAL HORN [J].

CHRISTENSEN, BN ;

PERL, ER .

JOURNAL OF NEUROPHYSIOLOGY, 1970, 33 (02) :293-+

[8] SPINOTHALAMIC LUMBOSACRAL LAMINA-I CELLS RESPONSIVE TO SKIN AND MUSCLE STIMULATION IN THE CAT [J].

CRAIG, AD ;

KNIFFKI, KD .

JOURNAL OF PHYSIOLOGY-LONDON, 1985, 365 (AUG) :197-221

[9]

CRAIG AD, 1991, SYMP PAIN R, P157

[10]

CRAIG AD, 1987, THALAMUS PAIN, P227

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