MONOCLONAL-ANTIBODY KI-67 - ITS USE IN HISTOPATHOLOGY

被引：594

作者：

BROWN, DC

GATTER, KC

机构：

[1] Nuffield Department of Pathology, John Radcliffe Hospital, Oxford

来源：

HISTOPATHOLOGY | 1990年 / 17卷 / 06期

关键词：

KI-67; ANTIBODY; PROLIFERATION INDEX; DIAGNOSTIC VALUE;

D O I：

10.1111/j.1365-2559.1990.tb00788.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Monoclonal antibody Ki-67 is a reliable and easy means of accurately assessing the growth fraction of human neoplasms. Although the number of long-term follow-up studies is limited, it does appear to provide valuable prognostic information particularly in lymphoproliferative disease. Since the estimation of growth fraction is only one factor influencing tumour behaviour it would be naive to believe that measurement of this parameter alone, no matter how accurately, would provide the clinician with definitive prognostic information for all tumours. The antibody is also of use in research, providing a means of measuring proliferative activity in a variety of conditions besides malignancy, and may prove of value in monitoring tumour response to established and trial therapies.

引用

页码：489 / 503

页数：15

共 149 条

[1]

ALLISON DC, 1985, CANCER RES, V45, P6010

[2] SIMULTANEOUS STAINING OF EXPONENTIALLY GROWING VERSUS PLATEAU PHASE CELLS WITH THE PROLIFERATION-ASSOCIATED ANTIBODY KI-67 AND PROPIDIUM IODIDE - ANALYSIS BY FLOW-CYTOMETRY [J].