ASYMMETRIC SYNTHESES OF 3-AMINO-2-METHYLPENTANOIC ACIDS - CONFIGURATIONS OF THE BETA-AMINO ACID IN MAJUSCULAMIDE C, 57-NORMAJUSCULAMIDE-C AND DOLASTATINS 11 AND 12

被引：20

作者：

BATES, RB

GANGWAR, S

机构：

[1] Department of Chemistry, University of Arizona, Tucson

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 01期

关键词：

D O I：

10.1016/S0957-4166(00)86016-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The first synthesis of 3-amino-2-methylpentanoic acids is reported. Comparison of the synthetic 2R,3R and 2L,3S acids with 3-amino-2-methylpentanoic acid obtained by degradation of the antifungal depsipeptide majusculamide C indicates that majusculamide C, 57-normajusculamide C, and the antitumor agents dolastatins 11 and 12 have the 2S,3R configurations at the chiral centers in their beta-amino acid component.

引用

页码：69 / 72

页数：4

共 8 条

[1] ENANTIOMERIC (Z)-CROTYLDIISOPINOCAMPHEYLBORANE AND (E)-CROTYLDIISOPINOCAMPHEYLBORANE - SYNTHESIS IN HIGH OPTICAL PURITY OF ALL 4 POSSIBLE STEREOISOMERS OF BETA-METHYLHOMOALLYL ALCOHOLS [J].