NERVE GROWTH-FACTOR ACTIVATES A RAS-DEPENDENT PROTEIN-KINASE THAT STIMULATES C-FOS TRANSCRIPTION PHOSPHORYLATION OF CREB

被引：690

作者：

GINTY, DD ^{[1
]}

BONNI, A ^{[1
]}

GREENBERG, ME ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, PROGRAM NEUROSCI, BOSTON, MA 02115 USA

来源：

CELL | 1994年 / 77卷 / 05期

关键词：

D O I：

10.1016/0092-8674(94)90055-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A mechanism by which the nerve growth factor (NGF) signal is transduced to the nucleus to induce gene expression has been characterized. An NGF-inducible, Ras-dependent protein kinase has been identified that catalyzes the phosphorylation of the cyclic AMP response element-binding protein (CREB) at Ser-133. Phosphorylation of Ser-133 stimulates the ability of CREB to activate transcription in NGF-treated cells. These findings suggest that CREB has a more widespread function than previously believed and functions in the nucleus as a general mediator of growth factor responses.

引用

页码：713 / 725

页数：13

共 53 条

[1] STIMULATION OF PROTEIN TYROSINE PHOSPHORYLATION BY NMDA RECEPTOR ACTIVATION [J].

BADING, H ;

GREENBERG, ME .

SCIENCE, 1991, 253 (5022) :912-914

[2] MULTIPLE SEQUENCE ELEMENTS OF A SINGLE FUNCTIONAL CLASS ARE REQUIRED FOR CYCLIC-AMP RESPONSIVENESS OF THE MOUSE C-FOS PROMOTER [J].

BERKOWITZ, LA ;

RIABOWOL, KT ;

GILMAN, MZ .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (10) :4272-4281

[3] SIGNAL-TRANSDUCTION VIA THE MAP KINASES - PROCEED AT YOUR OWN RSK [J].

BLENIS, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) :5889-5892

[4] A MECHANISM FOR SYNERGISTIC ACTIVATION OF A MAMMALIAN GENE BY GAL4 DERIVATIVES [J].

CAREY, M ;

LIN, YS ;

GREEN, MR ;

PTASHNE, M .

NATURE, 1990, 345 (6273) :361-364

[5]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[6] PHOSPHORYLATED CREB BINDS SPECIFICALLY TO THE NUCLEAR-PROTEIN CBP [J].

CHRIVIA, JC ;

KWOK, RPS ;

LAMB, N ;

HAGIWARA, M ;

MONTMINY, MR ;

GOODMAN, RH .

NATURE, 1993, 365 (6449) :855-859

[7] RAPAMYCIN FKBP SPECIFICALLY BLOCKS GROWTH-DEPENDENT ACTIVATION OF AND SIGNALING BY THE 70 KD S6 PROTEIN-KINASES [J].

CHUNG, J ;

KUO, CJ ;

CRABTREE, GR ;

BLENIS, J .

CELL, 1992, 69 (07) :1227-1236

[8] NERVE GROWTH-FACTOR INDUCES TRANSCRIPTION OF NGFIA THROUGH COMPLEX REGULATORY ELEMENTS THAT ARE ALSO SENSITIVE TO SERUM AND PHORBOL 12-MYRISTATE 13-ACETATE [J].

DEFRANCO, C ;

DAMON, DH ;

ENDOH, M ;

WAGNER, JA .

MOLECULAR ENDOCRINOLOGY, 1993, 7 (03) :365-379

[9] MULTIPLE SEQUENCE ELEMENTS IN THE C-FOS PROMOTER MEDIATE INDUCTION BY CAMP [J].

FISCH, TM ;

PRYWES, R ;

SIMON, MC ;

ROEDER, RG .

GENES & DEVELOPMENT, 1989, 3 (02) :198-211

[10] PHOSPHORYLATION OF TRANSCRIPTION FACTOR P62TCF BY MAP KINASE STIMULATES TERNARY COMPLEX-FORMATION AT C-FOS PROMOTER [J].

GILLE, H ;

SHARROCKS, AD ;

SHAW, PE .

NATURE, 1992, 358 (6385) :414-417

← 1 2 3 4 5 6 →