NONSTEROIDAL ANTIINFLAMMATORY DRUGS IN ALZHEIMERS-DISEASE

被引：394

作者：

RICH, JB ^{[1
]}

RASMUSSON, DX ^{[1
]}

FOLSTEIN, MF ^{[1
]}

CARSON, KA ^{[1
]}

KAWAS, C ^{[1
]}

BRANDT, J ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21287

来源：

NEUROLOGY | 1995年 / 45卷 / 01期

关键词：

D O I：

10.1212/WNL.45.1.51

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We reviewed the records of 210 patients in the Johns Hopkins Alzheimer's Disease Research Center to evaluate the role of nonsteroidal anti-inflammatory drugs (NSAIDs) on clinical features and progression of the disease. We compared patients taking NSAIDs or aspirin on a daily basis (N = 32) to non-NSAID patients (N = 177) on clinical, cognitive, and psychiatric measures. The NSAID group had a significantly shorter duration of illness at study entry. Even after controlling for this difference, the NSAID group performed better on the Mini-Mental State Examination, Boston Naming Test, and the delayed condition of the Benton Visual Retention Test. Furthermore, analysis of longitudinal changes over 1 year revealed less decline among NSAID patients than among non-NSAID patients on measures of verbal fluency, spatial recognition, and orientation. These findings support other recent studies suggesting that NSAIDs may serve a protective role in Alzheimer's disease.

引用

页码：51 / 55

页数：5

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