INTERLEUKIN-1-BETA AND INTERLEUKIN-6 RELEASE BY PERIPHERAL-BLOOD MONOCYTES IN HEAD AND NECK-CANCER

被引:24
作者
GALLO, O [1 ]
GORI, AM [1 ]
ATTANASIO, M [1 ]
MARTINI, F [1 ]
GIUSTI, B [1 ]
BODDI, M [1 ]
GALLINA, E [1 ]
FINI, O [1 ]
ABBATE, R [1 ]
机构
[1] UNIV FLORENCE, MED 1 CLIN, I-50134 FLORENCE, ITALY
关键词
D O I
10.1038/bjc.1993.371
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In patients with advanced head and neck squamous cell carcinoma (HNSC), evidence of cell-mediated immunity and monocyte functional abnormalities has been reported. We studied the production of interleukin 1 beta (IL-1beta) and interleukin 6 (IL-6) by peripheral blood monocytes from 22 patients with HNSC (12 larynx and ten oral cavity cancers) in comparison with monocyte cytokine production of age-matched healthy subjects. Pure monocytes were incubated with and without lipopolysaccarides (LPS) (10 mug ml-1) for 4 h at 37-degrees-C and IL-1beta and IL-6 concentrations were determined in supernatants by specific ELISA. There was no significant difference in IL-1beta levels in monocyte supernatants from cancer in comparison to control subjects; conversely, a higher IL-6 production by unstimulated and LPS-activated cells from HNSC patients than from controls was found. No relationship was observed between cytokine production and cancer stage. The regression analysis evidenced a significant correlation between IL-1beta and IL-6 monocyte-release in HNSC patients and in controls, so suggesting a possible autocrine control of IL-6 production by other cytokines.
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收藏
页码:465 / 468
页数:4
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