THE FREQUENCY OF REVERTANTS IN MDX MOUSE GENETIC MODELS FOR DUCHENNE MUSCULAR-DYSTROPHY

被引：123

作者：

DANKO, I

CHAPMAN, V

WOLFF, JA

机构：

[1] UNIV WISCONSIN,WAISMAN CTR,DEPT PEDIAT,1500 HIGHLAND AVE,MADISON,WI 53705

[2] NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,DEPT MOLEC & CELLULAR BIOL,BUFFALO,NY 14263

[3] UNIV WISCONSIN,WAISMAN CTR,DEPT MED GENET,MADISON,WI 53705

来源：

PEDIATRIC RESEARCH | 1992年 / 32卷 / 01期

关键词：

D O I：

10.1203/00006450-199207000-00025

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The mdx mouse has been used for the development of cellular and gene therapies for Duchenne muscular dystrophy. The relatively frequent occurrence of dystrophin-positive muscle cells called revertants has hampered these efforts by interfering with data interpretation. The mdx4cv and mdx5cv dystrophin mouse mutants have approximately 10-fold fewer revertants than the mdx mutant at both 2 and 6 mo. The mdx3cv dystrophin mouse mutant may be a useful model for some types of human dystrophin deficiencies in which the levels of dystrophin are low but not completely absent.

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页码：128 / 131

页数：4

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