INSULIN-LIKE GROWTH-FACTORS COUNTERACT THE EFFECT OF INTERLEUKIN-1-BETA ON TYPE-II PHOSPHOLIPASE-A2 EXPRESSION AND ARACHIDONIC-ACID RELEASE BY RABBIT ARTICULAR CHONDROCYTES

被引：32

作者：

BERENBAUM, F ^{[1
]}

THOMAS, G ^{[1
]}

POIRAUDEAU, S ^{[1
]}

BEREZIAT, G ^{[1
]}

CORVOL, MT ^{[1
]}

MASLIAH, J ^{[1
]}

机构：

[1] HOP ENFANTS MALAD,INSERM,U30,F-75743 PARIS 15,FRANCE

来源：

FEBS LETTERS | 1994年 / 340卷 / 1-2期

关键词：

PHOSPHOLIPASE A2; ARACHIDONIC ACID; CHONDROCYTE; INTERLEUKIN; 1-BETA; INSULIN-LIKE GROWTH FACTOR; ARTHRITIS;

D O I：

10.1016/0014-5793(94)80171-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin 1 beta was found to stimulate arachidonic acid release, and the synthesis and secretion of type II phospholipase A2 by rabbit articular chondrocytes in vitro. Interleukin 1 beta had no effect on the level of cytosolic phospholipase A2 mRNA. Insulin-like growth factors, which help stabilize the cartilage matrix, reduced the effect of interleukin 1 beta on type II phospholipase A2 activity and mRNA level, and decreased the Interleukin 1 beta-stimulated arachidonic acid release to the basal values. This suggests that type II phospholipase A2 plays a key role in arachidonic acid release from rabbit articular chondrocytes and that insulin-like growth factors counteract the effect of interleukin 1 beta They may therefore be considered as potential antiinflammatory agents.

引用

页码：51 / 55

页数：5

共 30 条

[1] INTERLEUKIN-1-MEDIATED PHOSPHOLIPID BREAKDOWN AND ARACHIDONIC-ACID RELEASE IN HUMAN SYNOVIAL-CELLS [J].