Electrophysiological changes in substantia nigra after striatal infarction

被引：4

作者：

Asai, T

Kataoka, K

Tokuno, T

Chichibu, S

Taneda, M

机构：

[1] KINKI UNIV,SCH MED,DEPT NEUROSURG,OSAKA 589,JAPAN

[2] KINKI UNIV,SCH MED,DEPT PHYSIOL 1,OSAKA 589,JAPAN

来源：

NEUROREPORT | 1995年 / 7卷 / 01期

关键词：

cerebral ischaemia; middle cerebral artery occlusion; rat; striatum; substantia nigra pars reticulata; unit recording;

D O I：

10.1097/00001756-199512000-00040

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE GABAergic efferent pathway from the striatum exerts inhibitory control on the substantia nigra pars reticulata (SNR) neurones. We studied sequential changes in spontaneous single-unit activities in the ipsilateral SNR 1 h, 1 day, 7 days and 14 days after striatal infarction induced by middle cerebral artery occlusion (MCAO) in rats. Compared with a sham-operated group, there was no change in the firing rate Ih after MCAO, and one day after MCAO the mean firing rate decreased. The firing rate of SNR neurones at 7 and 14 days after MCAO was significantly reduced compared with the sham-operated group. Only two neurones (sham-operated group and Ih after MCAO group) fired with high frequency. Histological examination revealed degeneration of the ipsilateral SNR 7 and 14 days after MCAO. Our results indicated that SNR neuronal degeneration accompanied by striatal ischaemia does not simply depend on hyperexcitation due to the activation of a disinhibition mechanism.

引用

页码：165 / 168

页数：4

共 25 条

[1] THE INFLUENCE OF STRIATUM ON THE SUBSTANTIA NIGRA - A STUDY USING THE SPREADING DEPRESSION TECHNIQUE [J].