THEORETICAL-STUDIES OF PROTEIN FOLDING

被引：743

作者：

GO, N

机构：

来源：

ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING | 1983年 / 12卷

关键词：

AMINO ACIDS - BIOCHEMISTRY - CHEMICAL REACTIONS - STATISTICAL METHODS;

D O I：

10.1146/annurev.bb.12.060183.001151

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The folding-unfolding transition in small globular proteins can be described in general as a two-state equilibrium process, the transition being similar to a first-order phase transition. Many models of the folding process or the folding-unfolding transition have been proposed and studied in recent years. This review analyses the physical bases of these various models. Analyses from the statistical physical point of view are emphasized. Methods of prediction are discussed only when they have implications regarding the mechanism of the folding-unfolding transition.

引用

页码：183 / 210

页数：28

共 93 条

[1] NON-INTERACTING LOCAL-STRUCTURE MODEL OF FOLDING AND UNFOLDING TRANSITION IN GLOBULAR-PROTEINS .2. APPLICATION TO TWO-DIMENSIONAL LATTICE PROTEINS [J].