FACILITATORY ROLE OF CALCITONIN GENE-RELATED PEPTIDE (CGRP) ON EXCITATION INDUCED BY SUBSTANCE-P (SP) AND NOXIOUS STIMULI IN RAT SPINAL DORSAL HORN NEURONS - AN IONTOPHORETIC STUDY INVIVO

被引：98

作者：

BIELLA, G

PANARA, C

PECILE, A

SOTGIU, ML

机构：

[1] UNIV MILAN,DIPARTIMENTO FARMACOL CHEMIOTERAPIA & TOSSICOL MED,I-20122 MILAN,ITALY

[2] CNR,IST FISIOL CENT NERVOSI,I-20133 MILAN,ITALY

来源：

BRAIN RESEARCH | 1991年 / 559卷 / 02期

关键词：

SUBSTANCE-P; CALCITONIN GENE-RELATED PEPTIDE; NOCICEPTIVE TRANSMISSION; MODULATORY INTERACTION;

D O I：

10.1016/0006-8993(91)90024-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of iontophoretically applied calcitonin gene-related peptide (CGRP) and/or substance P (SP) onto physiologically identified neurons in the rat lumbar dorsal horn were studied. The consistent excitatory effects of SP found on the spontaneous and the noxious evoked activity were significantly potentiated by CGRP application. This peptide facilitated the noxious evoked activity and did not affect the spontaneous activity of the neurons. The responses to non-noxious stimuli were unaffected in all cases.

引用

页码：352 / 356

页数：5

共 30 条

[1] ORIGIN, DISTRIBUTION AND SYNAPTIC RELATIONSHIPS OF SUBSTANCE-P AXONS IN RAT SPINAL-CORD [J].