ADMINISTRATION OF AMYLOID BETA-PEPTIDES INTO THE MEDIAL SEPTUM OF RATS DECREASES ACETYLCHOLINE-RELEASE FROM HIPPOCAMPUS IN-VIVO

被引：78

作者：

ABE, E

CASAMENTI, F

GIOVANNELLI, L

SCALI, C

PEPEU, G

机构：

[1] UNIV FLORENCE,DEPT PRECLIN & CLIN PHARMACOL,I-50134 FLORENCE,ITALY

[2] IWATE MED UNIV,SCH DENT,DEPT PHARMACOL,MORIOKA,IWATE 020,JAPAN

来源：

BRAIN RESEARCH | 1994年 / 636卷 / 01期

关键词：

ALZHEIMERS DISEASE; AMYLOID BETA-PEPTIDES; ACETYLCHOLINE RELEASE; MICRODIALYSIS; SEPTOHIPPOCAMPAL PATHWAY;

D O I：

10.1016/0006-8993(94)90193-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The septum of male Wistar rats was injected with synthetic beta-amyloid fragments, beta(12-28), beta(25-35) and beta(1-40), and hippocampal acetylcholine (ACh) release was evaluated by transversal microdialysis. A marked decrease in basal and K+-evoked ACh release was found 7 or 21 days after injection of 5 nmol of beta(12-28) and beta(25-35), or 3 nmol of beta(1-40), respectively. These data indicate that septal injection of beta-amyloid peptides causes hypofunction of the septo-hippocampal cholinergic system.

引用

收藏

页码：162 / 164

页数：3

相关论文

共 13 条

[1] THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].

BARTUS, RT ;

DEAN, RL ;

BEER, B ;

LIPPA, AS .

SCIENCE, 1982, 217 (4558) :408-417

[2] PHOSPHATIDYLSERINE REVERSES THE AGE-DEPENDENT DECREASE IN CORTICAL ACETYLCHOLINE-RELEASE - A MICRODIALYSIS STUDY [J].

CASAMENTI, F ;

SCALI, C ;

PEPEU, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 194 (01) :11-16

[3] ACTION OF AMYLOID BETA-PROTEIN ON PROTEIN-KINASE-C ACTIVITY [J].

CHAUHAN, A ;

CHAUHAN, VPS ;

BROCKERHOFF, H ;

WISNIEWSKI, HM .

LIFE SCIENCES, 1991, 49 (21) :1555-1562

[4] IMPLANTS CONTAINING BETA-AMYLOID PROTEIN ARE NOT NEUROTOXIC TO YOUNG AND OLD RAT-BRAIN [J].

CLEMENS, JA ;

STEPHENSON, DT .

NEUROBIOLOGY OF AGING, 1992, 13 (05) :581-586

[5]

DASCHMANN B, 1988, ARCH INT PHARMACOD T, V296, P232

[6] RAPID RADIOCHEMICAL METHOD FOR DETERMINATION OF CHOLINE-ACETYLTRANSFERASE [J].

FONNUM, F .

JOURNAL OF NEUROCHEMISTRY, 1975, 24 (02) :407-409

[7] AGGREGATION AND SECONDARY STRUCTURE OF SYNTHETIC AMYLOID BETA-A4 PEPTIDES OF ALZHEIMERS-DISEASE [J].

HILBICH, C ;

KISTERSWOIKE, B ;

REED, J ;

MASTERS, CL ;

BEYREUTHER, K .

JOURNAL OF MOLECULAR BIOLOGY, 1991, 218 (01) :149-163

[8] THE PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID-A4 PROTEIN RESEMBLES A CELL-SURFACE RECEPTOR [J].

KANG, J ;

LEMAIRE, HG ;

UNTERBECK, A ;

SALBAUM, JM ;

MASTERS, CL ;

GRZESCHIK, KH ;

MULTHAUP, G ;

BEYREUTHER, K ;

MULLERHILL, B .

NATURE, 1987, 325 (6106) :733-736

[9] INVIVO NEUROTOXICITY OF BETA-AMYLOID [BETA(1-40)] AND THE BETA(25-35) FRAGMENT [J].

KOWALL, NW ;

MCKEE, AC ;

YANKNER, BA ;

BEAL, MF .

NEUROBIOLOGY OF AGING, 1992, 13 (05) :537-542

[10] CORRELATION OF CHOLINERGIC ABNORMALITIES WITH SENILE PLAQUES AND MENTAL TEST-SCORES IN SENILE DEMENTIA [J].

PERRY, EK ;

TOMLINSON, BE ;

BLESSED, G ;

BERGMANN, K ;

GIBSON, PH ;

PERRY, RH .

BRITISH MEDICAL JOURNAL, 1978, 2 (6150) :1457-1459