ANTI-POLYSACCHARIDE IMMUNOGLOBULIN ISOTYPE LEVELS AND OPSONIC ACTIVITY OF ANTISERA - RELATIONSHIPS WITH PROTECTION AGAINST STREPTOCOCCUS-PNEUMONIAE INFECTION IN MICE

被引：46

作者：

DEVELASCO, EA ^{[1
]}

DEKKER, BAT ^{[1
]}

VERHEUL, AFM ^{[1
]}

FELDMAN, RG ^{[1
]}

VERHOEF, J ^{[1
]}

SNIPPE, H ^{[1
]}

机构：

[1] UNIV UTRECHT, EIJKMAN WINKLER INST MED & CLIN MICROBIOL, 3584 CX UTRECHT, NETHERLANDS

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 172卷 / 02期

关键词：

D O I：

10.1093/infdis/172.2.562

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Relationships between in vitro parameters (opsonic activity and anti-pneumococcal polysaccharide [PS] antibody subclasses) and in vivo mouse protection were established by logistic regression analysis. Data were from 158 mice challenged with pneumococci after vaccination with synthetic oligosaccharide- and PS-protein conjugates in combination with the adjuvant Quil A. The hypothesis that serum opsonic activity has predictive value for protection against pneumococcal infection was tested. Serum opsonic activity was well correlated with protection (chi(2) = 35.5, P < .001), although a stronger correlation was observed for anti-PS IgM and IgG. The combined use of IgG and opsonic activity as predictor variables yielded the best fitting model for predicting protection (chi(2) = 74.1, P < .001). When opsonic activity data were added to models that included various antibody isotypes, the statistical significance of the models was enhanced. Thus, the opsonic activity of antisera induced by pneumococcal vaccines can predict mouse protection.

引用

页码：562 / 565

页数：4

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