THE MICROTUBULE BINDING REPEATS OF TAU PROTEIN ASSEMBLE INTO FILAMENTS LIKE THOSE FOUND IN ALZHEIMERS-DISEASE

被引：157

作者：

CROWTHER, RA

OLESEN, OF

JAKES, R

GOEDERT, M

机构：

[1] Medical Research Council, Laboratory of Molecular Biology, Cambridge, CB2 2QH, Hills Road

来源：

FEBS LETTERS | 1992年 / 309卷 / 02期

关键词：

ALZHEIMERS DISEASE; MICROTUBULE-ASSOCIATED PROTEIN TAU; PAIRED HELICAL FILAMENT;

D O I：

10.1016/0014-5793(92)81094-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The paired helical filament, which comprises the major fibrous element of the neurofibrillary tangle in Alzheimer's disease, contains abnormally phosphorylated microtubule-associated protein tau as its principal constituent. The repeat region of tau protein, which represents the microtubule binding domain, forms the core of the filament. Here we show that an expressed fragment of tau protein spanning the repeat region can assemble in vitro into filaments like those found in Alzheimer's disease

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页码：199 / 202

页数：4

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