DIAZOXIDE SUPPRESSES SLOWLY-INACTIVATING OUTWARD AND INWARD CURRENTS IN CA1 HIPPOCAMPAL-NEURONS

被引:10
作者
ERDEMLI, G
KRNJEVIC, K
机构
[1] Anaesthesia Research Department, McGill University, Quebec
关键词
K-ATP CHANNELS; TTX-SENSITIVE NA CURRENT; CA;
D O I
10.1097/00001756-199312000-00016
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
DIAZOXIDE (DZX) opens ATP-sensitive K (K-ATP) channels in muscle and other cells. In whole-cell voltage-clamp recordings in slices, in the presence of kynurenate and bicuculline to minimize indirect effects, DZX (0.65 mM) did not increase input conductance; but it sharply reduced persistent inward and outward currents. An inward current (peak near -20 mV) was especially clear in the presence of K channel blockers; was fully evident in Ca-channel blocking medium; but was abolished by tetrodotoxin. The main direct effects of DZX on these neurones are thus mediated not by activation of K-ATP channels, but rather by modulation of voltage-dependent channels, including a TTX-sensitive persistent Na current and possibly a Ca current.
引用
收藏
页码:249 / 251
页数:3
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