THE IMPORTANCE OF STEREOCHEMISTRY IN THE CLINICAL PHARMACOKINETICS OF THE 2-ARYLPROPIONIC ACID NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

被引：217

作者：

HUTT, AJ ^{[1
]}

CALDWELL, J ^{[1
]}

机构：

[1] UNIV LONDON,ST MARYS HOSP,SCH MED,DEPT PHARMACOL,LONDON W2 1PG,ENGLAND

来源：

CLINICAL PHARMACOKINETICS | 1984年 / 9卷 / 04期

关键词：

D O I：

10.2165/00003088-198409040-00007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：371 / 373

页数：3

共 20 条

[1] PHARMACOLOGICAL DIFFERENCES BETWEEN OPTICAL ISOMERS OF IBUPROFEN - EVIDENCE FOR METABOLIC INVERSION OF (-)-ISOMER [J].

ADAMS, SS ;

BRESLOFF, P ;

MASON, CG .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1976, 28 (03) :256-257

[2]

BOPP RJ, 1979, DRUG METAB DISPOS, V7, P356

[3] BIOLOGICAL-ACTIVITY OF INDOPROFEN AND ITS OPTICAL ISOMERS [J].

BUTTINONI, A ;

FERRARI, M ;

COLOMBO, M ;

CESERANI, R .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1983, 35 (09) :603-604

[4] SEPARATION AND DETERMINATION OF NAPROXEN ENANTIOMERS IN SERUM BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

GOTO, J ;

GOTO, N ;

NAMBARA, T .

JOURNAL OF CHROMATOGRAPHY, 1982, 239 (APR) :559-564

[5] ANTAGONISM OF SLOW REACTING SUBSTANCE IN ANAPHYLAXIS(SRS-A) AND OTHER SPASMOGENS ON GUINEA-PIG TRACHEAL CHAIN BY HYDRATROPIC ACIDS AND THEIR EFFECTS ON ANAPHYLAXIS [J].

GREIG, ME ;

GRIFFIN, RL .

JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (01) :112-116

[6] NONSTEROIDAL ANTIINFLAMMATORY AGENTS .1. 6-SUBSTITUTED 2-NAPHTHYLACETIC ACIDS [J].

HARRISON, IT ;

LEWIS, B ;

NELSON, P ;

ROOKS, W ;

ROSZKOWS.A ;

TOMOLONI.A ;

FRIED, JH .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (02) :203-&

[7] THE METABOLIC CHIRAL INVERSION OF 2-ARYLPROPIONIC ACIDS - A NOVEL ROUTE WITH PHARMACOLOGICAL CONSEQUENCES [J].

HUTT, AJ ;

CALDWELL, J .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1983, 35 (11) :693-704

[8]

JENNER P, 1973, DRUG METAB REV, V2, P117

[9] STEREOSPECIFIC ASSAY AND STEREOSPECIFIC DISPOSITION OF RACEMIC CARPROFEN IN RATS [J].

KEMMERER, JM ;

RUBIO, FA ;

MCCLAIN, RM ;

KOECHLIN, BA .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1979, 68 (10) :1274-1280

[10] INHIBITION OF PROSTAGLANDIN SYNTHASE BY PIRPROFEN - STUDIES WITH SHEEP SEMINAL-VESICLE ENZYME [J].

KU, EC ;

WASVARY, JM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 384 (02) :360-368

← 1 2 →