TRANSCRIPTIONAL REGULATION OF THE SACCHAROMYCES-CEREVISIAE HXK1, HXK2 AND GLK1 GENES

被引：116

作者：

HERRERO, P ^{[1
]}

GALINDEZ, J ^{[1
]}

RUIZ, N ^{[1
]}

MARTINEZCAMPA, C ^{[1
]}

MORENO, F ^{[1
]}

机构：

[1] UNIV OVIEDO,INST UNIV BIOTECHNOL ASTURIAS,DEPT BIOL FUNCT BIOQUIM & BIOL MOLEC,E-33006 OVIEDO,SPAIN

来源：

YEAST | 1995年 / 11卷 / 02期

关键词：

SACCHAROMYCES CEREVISIAE; HXK1; HXK2; GLK1; MESSENGER-RNA; TRANSCRIPTIONAL CONTROL;

D O I：

10.1002/yea.320110205

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In Saccharomyces cerevisiae, the transcriptional regulation of most glycolytic genes has been extensively studied. By contrast, little is known about the transcriptional control of the three glucose-phosphorylating enzymes, although this catalytic reaction has an important role in the regulation of cell metabolism. In this paper, we describe the transcriptional regulation of the HXK1, HXK2 and GLK1 genes in the hope of revealing differences in the steady-state levels of mRNA associated with a particular carbon source used in the culture medium. Our results provide evidence supporting a differential expression of the three genes depending on the carbon source used for growth. We have also studied the induction and repression kinetics of mRNA expression for the HXK1, HXK2 and GLK1 genes.

引用

页码：137 / 144

页数：8

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