THE INDUCTION OF LTP INCREASES BDNF AND NGF MESSENGER-RNA BUT DECREASES NT-3 MESSENGER-RNA IN THE DENTATE GYRUS

被引：277

作者：

CASTREN, E ^{[1
]}

PITKANEN, M ^{[1
]}

SIRVIO, J ^{[1
]}

PARSADANIAN, A ^{[1
]}

LINDHOLM, D ^{[1
]}

THOENEN, H ^{[1
]}

RIEKKINEN, PJ ^{[1
]}

机构：

[1] UNIV KUOPIO,DEPT NEUROL,KUOPIO,FINLAND

来源：

NEUROREPORT | 1993年 / 4卷 / 07期

关键词：

NEUROTROPHINS; NT-4; TRKB; LONG-TERM POTENTIATION; IN-SITU HYBRIDIZATION; HIPPOCAMPUS; SYNAPTIC PLASTICITY;

D O I：

10.1097/00001756-199307000-00014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE have investigated the expression of the mRNAs for brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) in the hippocampus before and after induction of long term potentiation (LTP) of synaptic transmission in the dentate gyrus through stimulation of the perforant path (PP). A unilateral PP stimulation produced a bilateral increase in the mRNA for both BDNF and NGF in granular neurones of the dentate gyrus but not in other neurones in the hippocampus. The mRNA for neurotrophin-3 (NT-3) was bilaterally decreased by LTP but that of NT-4 remained at the basal level. These results suggest that individual neurotrophic factors may play different roles in neuronal plasticity.

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页码：895 / 898

页数：4

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