ROLE OF FAS LIGAND IN APOPTOSIS INDUCED BY HEPATITIS-C VIRUS-INFECTION

被引：174

作者：

MITA, E ^{[1
]}

HAYASHI, N ^{[1
]}

IIO, S ^{[1
]}

TAKEHARA, T ^{[1
]}

HIJIOKA, T ^{[1
]}

KASAHARA, A ^{[1
]}

FUSAMOTO, H ^{[1
]}

KAMADA, T ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT MED 1,SUITA,OSAKA 565,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 204卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.2483

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To investigate the role that Fas ligand plays in the apoptosis of hepatocytes induced by hepatitis C virus infection, we isolated a cDNA clone for human Fas ligand and examined the expression of Fas ligand in liver-infiltrating mononuclear cells obtained from patients with chronic hepatitis C. The amino acid sequence of human Fas ligand showed 76% and 77% identity with those of rat and mouse Fas ligand, respectively. When the expression of Fas ligand transcripts was tested by reverse transcription-polymerase chain reaction, the amplified signal was detected in liver-infiltrating mononuclear cells and peripheral blood mononuclear cells, whereas only a weak signal or none at all was detected in liver tissues. These findings suggest that the Fas ligand-Fas antigen system may play an important role in liver cell injury by hepatitis C virus infection. (C) 1994 Academic Press, Inc.

引用

页码：468 / 474

页数：7

共 18 条

[1]

CERNY A, 1994, VIRAL HEPATITIS LIVE, P190

[2] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].