ROLE OF ABERRANT CRYPT FOCI IN UNDERSTANDING THE PATHOGENESIS OF COLON-CANCER

被引：490

作者：

BIRD, RP

机构：

[1] Department of Foods and Nutrition, University of Manitoba, Winnipeg

来源：

CANCER LETTERS | 1995年 / 93卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

ABERRANT CRYPT FOCI; PRENEOPLASTIC LESIONS; COLON CARCINOGENESIS;

D O I：

10.1016/0304-3835(95)03788-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aberrant crypt foci (ACF) are present in carcinogen treated rodent colons and in the colons of humans with a high risk for developing the disease. It is proposed that ACF are preneoplastic lesions. Quantification of the number and growth features of ACF has been employed to study modulators of colon carcinogenesis. In this review, examples are presented to support the concept that ACF are preneoplastic lesions and that sequential quantification of their number and growth features (crypt multiplicity) in animal colons may provide further insight into the pathogenesis of colon cancer. It is proposed that cellular and molecular heterogeneity among ACF with different growth and morphologic features will be invaluable in the identification of events critically associated with cancer development.

引用

页码：55 / 71

页数：17

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