GABA(C) RECEPTORS

被引：260

作者：

BORMANN, J ^{[1
]}

FEIGENSPAN, A ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT NEUROBIOL,BOSTON,MA 02115

来源：

TRENDS IN NEUROSCIENCES | 1995年 / 18卷 / 12期

关键词：

D O I：

10.1016/0166-2236(95)98370-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

gamma-Aminobutyric acid (GABA) is an important neurotransmitter that mediates inhibition in the vertebrate CNS. Until recently, two receptor subtypes were known: bicuculline-sensitive GABA(A) and baclofen-sensitive GABA(B) receptors. Several lines of evidence now indicate the existence of a third class of GABA receptor, which is distinct pharmacologically from GABA(A) and GABA(B) receptors and is found predominantly in the vertebrate retina. These novel GABA(C) receptors are CI- pores. They are insensitive to drugs that modulate GABA(A) and GABA(B) receptors and are activated selectively by cis-4-aminocrotonic acid.

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页码：515 / 519

页数：5

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