THE METABOTROPIC GLUTAMATE-RECEPTOR (MGLUR1-ALPHA) IS CONCENTRATED AT PERISYNAPTIC MEMBRANE OF NEURONAL SUBPOPULATIONS AS DETECTED BY IMMUNOGOLD REACTION

被引：790

作者：

BAUDE, A ^{[1
]}

NUSSER, Z ^{[1
]}

ROBERTS, JDB ^{[1
]}

MULVIHILL, E ^{[1
]}

MCILHINNEY, RAJ ^{[1
]}

SOMOGYI, P ^{[1
]}

机构：

[1] ZYMOGENET INC, SEATTLE, WA 98105 USA

来源：

NEURON | 1993年 / 11卷 / 04期

关键词：

D O I：

10.1016/0896-6273(93)90086-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An antiserum to mGluR1alpha labeled a 160 kd protein in immunoblots of membranes derived from rat brain or cells transfected with mGluR1alpha. Immunoreactivity for mGluR1alpha was present in discrete subpopulations of neurons. The GABAergic neurons of the cerebellar cortex were strongly immunoreactive; only some Golgi cells were immunonegative. Somatostatin/GABA-immunopositive cells in the neocortex and hippocampus were enriched in mGluR1alpha. The hippocampal cells had spiny dendrites that were precisely codistributed with the local axon collaterals of pyramidal and granule cells. Electron microscopic immunometal detection of mGluR1alpha showed a preferential localization at the periphery of the extensive postsynaptic densities of type 1 synapses in both the cerebellum and the hippocampus. The receptor was also present at sites in the dendritic and somatic membrane where synapses were not located.

引用

页码：771 / 787

页数：17

共 73 条

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