REACTIONS OF FORSKOLIN, A BIOLOGICALLY-ACTIVE DITERPENOID FROM COLEUS-FORSKOHLII

被引:73
作者
BHAT, SV
BAJWA, BS
DORNAUER, H
DESOUZA, NJ
机构
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1982年 / 03期
关键词
D O I
10.1039/p19820000767
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Forskolin (7.beta.-acetoxy-8,13-epoxy-1.alpha.,6.beta.,9.alpha.-trihydroxylabd-14-en-11-one), the major diterpenoid of C. forskohlii, has potent positive inotropic, antihypertensive and adenylate cyclase stimulant properties. The reactivity of its various functional groups (1.alpha.-OH, 6.beta.-OH, the derived 7.beta.-OH, 9.alpha.-OH, 11-oxo and 14,15-double bond) was studied through acylation, alkylation, dehydration, oxidation and reduction reactions.
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页码:767 / 771
页数:5
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