APPEARANCE OF INTERLEUKIN-1 IN MACROPHAGES AND IN RAMIFIED MICROGLIA IN THE BRAIN OF ENDOTOXIN-TREATED RATS - A PATHWAY FOR THE INDUCTION OF NONSPECIFIC SYMPTOMS OF SICKNESS

被引：298

作者：

VANDAM, AM ^{[1
]}

BROUNS, M ^{[1
]}

LOUISSE, S ^{[1
]}

BERKENBOSCH, F ^{[1
]}

机构：

[1] FREE UNIV AMSTERDAM, FAC MED, DEPT PHARMACOL, V-D BOECHORSST 7, 1081 BT AMSTERDAM, NETHERLANDS

来源：

BRAIN RESEARCH | 1992年 / 588卷 / 02期

关键词：

INTERLEUKIN-1; BRAIN; MACROPHAGE; PERIVASCULAR CELL; MICROGLIA; ENDOTOXIN; SICKNESS;

D O I：

10.1016/0006-8993(92)91588-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The presence and cellular localization of interleukin-1-beta immunoreactivity (irIL-1) in and around the brain was investigated using immunocytochemistry on Bouin's fixed vibratome brain sections of control and endotoxin-treated rats. Peripheral administration of endotoxin resulted in the appearence of irIL-1 in cells in the meninges, choroid plexus, brain blood vessels and in non-neuronal cells in the brain parenchyma. Using monoclonal and polyclonal antibodies to macrophage and astrocyte antigens, the endotoxin-induced irIL-1 positive cells could be identified as macrophages in the meninges and choroid plexus (ED2), perivascular cells (ED2) and ramified microglial cells (GSA-1-B4 isolectin). Our data demonstrate a pathway for the induction of non-specific sickness symptoms in response to endotoxin.

引用

页码：291 / 296

页数：6

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