GENETIC-LINKAGE MAP OF 46 DNA MARKERS ON HUMAN CHROMOSOME-16

被引：36

作者：

KEITH, TP ^{[1
]}

GREEN, P ^{[1
]}

REEDERS, ST ^{[1
]}

BROWN, VA ^{[1
]}

PHIPPS, P ^{[1
]}

BRICKER, A ^{[1
]}

FALLS, K ^{[1
]}

REDIKER, KS ^{[1
]}

POWERS, JA ^{[1
]}

HOGAN, C ^{[1
]}

NELSON, C ^{[1
]}

KNOWLTON, R ^{[1
]}

DONISKELLER, H ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP,NUFFIELD DEPT CLIN MED,OXFORD OX3 9DU,ENGLAND

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 15期

关键词：

Autosomal dominant polycystic kidney disease; Multipoint linkage analysis; Restriction fragment length polymorphisms;

D O I：

10.1073/pnas.87.15.5754

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have constructed a genetic linkage map of human chromosome 16 based on 46 DNA markers that detect restriction fragment length polymorphisms. Segregation data were collected on a set of multigenerational families provided by the Centre d'Etude du Polymorphisme Humain, and maps were constructed using recently developed multipoint analysis techniques. The map spans 115 centimorgans (cM) in males and 193 cM in females. Over much of the chromosome there is a significantly higher frequency of recombination in females than males. Near the α-globin locus on the distal part of the short arm, however, there is a significant excess of male recombination. Twenty-seven (59%) of the markers on the map have heterozygosities greater than or equal to 0.50. The largest interval between loci on the sex-average map is 14 cM and the average marker spacing is 3 cM. Using loci on this map, one could detect linkage to a dominant disease on chromosome 16 with as few as 10-15 phase-known meioses. (.

引用

页码：5754 / 5758

页数：5

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