ALTERED EXPRESSION OF TRANSFORMING GROWTH-FACTOR-BETA IN ALZHEIMERS-DISEASE

被引：130

作者：

FLANDERS, KC

LIPPA, CF

SMITH, TW

POLLEN, DA

SPORN, MB

机构：

[1] UNIV MASSACHUSETTS,MED CTR,DEPT NEUROL,WORCESTER,MA 01655

[2] UNIV MASSACHUSETTS,MED CTR,DEPT PATHOL,WORCESTER,MA 01655

[3] NCI,CHEMOPREVENT LAB,BETHESDA,MD 20892

来源：

NEUROLOGY | 1995年 / 45卷 / 08期

关键词：

D O I：

10.1212/WNL.45.8.1561

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We compared immunohistochemical expression of the transforming growth factor-beta s (TGF-beta 1, TGF-beta 2, and TGF-beta 3) using brain tissue from patients with nondominantly inherited Alzheimer's disease (NDAD) (n = 9), autosomal dominantly inherited Alzheimer's disease with linkage to 14q24.3 (FAD-14) (n = 4); and cognitively normal controls (n = 10) to determine whether their pathologic changes are associated with an altered distribution of the TGF-beta s. We found increased expression of TGF-beta 2 in large, tangle-bearing neurons with widespread staining of glia in NDAD and FAD-14 patients compared with control cases. This result was confirmed with sandwich ELISA assays of brain tissue, which showed TGF-beta 2 levels in AD and NDAD to average 3.2 times the average level of control cases. Despite proximity of TGF-beta 1 and TGF-beta 3 to the sites of susceptibility loci on chromosomes 19 and 14, we did not find that TGF-beta 1 and TGF-beta 3 were selectively altered in any AD subtypes. However, selective induction of TGF-beta 2 may occur in NDAD and FAD-14.

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页码：1561 / 1569

页数：9

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