CHRONIC HANDLING MODIFIES THE ANXIOLYTIC EFFECT OF DIAZEPAM IN THE ELEVATED PLUS-MAZE

被引：63

作者：

BRETT, RR ^{[1
]}

PRATT, JA ^{[1
]}

机构：

[1] UNIV STRATHCLYDE,DEPT PHYSIOL & PHARMACOL,GEORGE ST,GLASGOW G1 1XW,SCOTLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 178卷 / 01期

基金：

英国惠康基金;

关键词：

(Rat); Anxiety; Diazepam; Elevated plus-maze; Habituation; Handling;

D O I：

10.1016/0014-2999(90)94806-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rats treated for 3 days with diazepam demonstrated a clear anxiolytic action of the drug as assessed in the elevated plus-maze. However, in a chronic experiment, in which all rats were handled for 28 days, no anxiolytic effect of diazepam could be shown either in rats treated for 3 days or in those treated for 28 days. These results suggest that there is an interaction between handling and the anxiolytic effect of diazepam. © 1990.

引用

页码：135 / 138

页数：4

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