THYMIC SELECTION - A MATTER OF LIFE AND DEATH

被引：168

作者：

VONBOEHMER, H

机构：

[1] Harald von Boehmer is at the Basel Institute for Immunology, CH-4005 Basel

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 11期

关键词：

D O I：

10.1016/0167-5699(92)90075-I

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mice transgenic for the T-cell receptor (TCR) were instrumental to the understanding that developing alphabeta T cells undergo programmed cell death unless the TCRbeta gene properly rearranges and produces receptors of appropriate specificity. The delineation of developmental pathways for 'conventional' alphabeta T cells bas resulted in the recognition of a different lineage of alphabeta T cells that develop in the thymus, the function of which remains to be elucidated.

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页码：454 / 458

页数：5

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