HEAT-SHOCK PROTEINS IN THE HUMAN PERIODONTAL-DISEASE PROCESS

被引：54

作者：

ANDO, T ^{[1
]}

KATO, T ^{[1
]}

ISHIHARA, K ^{[1
]}

OGIUCHI, H ^{[1
]}

OKUDA, K ^{[1
]}

机构：

[1] TOKYO DENT COLL,DEPT MICROBIOL,CHIBA 261,JAPAN

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1995年 / 39卷 / 05期

关键词：

PERIODONTITIS; PERIODONTOPATHIC BACTERIA; HEAT SHOCK PROTEIN; IMMUNOPATHOLOGY;

D O I：

10.1111/j.1348-0421.1995.tb02208.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The production of HSP by periodontopathic Gram-negative bacteria was examined by SDS-PAGE, two dimensional gel electrophoresis, and Western blotting using monoclonal antibodies against HSPs. Strains of Actinobacillus actinomycetemcomitans, Eikenella corrodens, Fusobacterium nucleatum, Prevotella intermedia, Prevotella nigrescens, Prevotella melaninogenica, and Treponema socranskii species produced HSP which reacted with anti-Yersinia enterocolitica HSP 60 and/or mycobacterial 65-kDa HSP monoclonal antibodies. It was found that gingival homogenate samples from patients with adult periodontitis reacted with anti-human HSP 60 and bovine brain HSP 70 monoclonal antibodies. Antibodies which reacted with bacterial HSP were also found in a serum sample from a periodontitis patient. The present study suggests that HSPs are implicated in the human periodontal disease process.

引用

页码：321 / 327

页数：7

共 19 条

[1] 2 MONOCLONAL-ANTIBODIES GENERATED AGAINST HUMAN HSP60 SHOW REACTIVITY WITH SYNOVIAL MEMBRANES OF PATIENTS WITH JUVENILE CHRONIC ARTHRITIS [J].