Natural history of untreated cytomegalovirus retinitis

被引：44

作者：

Bowen, EF

Wilson, P

Atkins, M

Madge, S

Griffiths, PD

Johnson, MA

Emery, VC

机构：

[1] ROYAL FREE HOSP,SCH MED,DEPT THORAC MED & HIV MED,LONDON NW3 2PF,ENGLAND

[2] ROYAL FREE HOSP,SCH MED,DEPT OPHTHALMOL,LONDON NW3 2PF,ENGLAND

来源：

LANCET | 1995年 / 346卷 / 8991-2期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0140-6736(95)92842-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cytomegalovirus infection is common in patients with AIDS, and often causes retinitis. Treatment is rarely curative, but the progression of retinitis is delayed. The untreated course of cytomegalovirus retinitis in AIDS is unknown. We report a 35-year-old man with retinitis who refused treatment. Retinitis resulted in blindness within 6 months. Measurement of cytomegalovirus genomes showed an increasing viral load in blood and urine.

引用

页码：1671 / 1673

页数：3

共 8 条

[1] QUANTIFICATION OF HUMAN CYTOMEGALOVIRUS DNA USING THE POLYMERASE CHAIN-REACTION [J].

FOX, JC ;

GRIFFITHS, PD ;

EMERY, VC .

JOURNAL OF GENERAL VIROLOGY, 1992, 73 :2405-2408

[2] INCIDENCE AND NATURAL-HISTORY OF CYTOMEGALOVIRUS DISEASE IN PATIENTS WITH ADVANCED HUMAN-IMMUNODEFICIENCY-VIRUS DISEASE TREATED WITH ZIDOVUDINE [J].

GALLANT, JE ;

MOORE, RD ;

RICHMAN, DD ;

KERULY, J ;

CHAISSON, RE ;

BARTLETT, J ;

MCAVINUE, S ;

BRYSON, Y ;

COHEN, H ;

FISCHL, M ;

BOLIN, T ;

KESSLER, H ;

BURROUGH, Y ;

MILDVAN, D ;

FOX, A ;

RICHMAN, D ;

FREEMAN, B ;

SIMON, G ;

GRABOWY, KW ;

CHERNOFF, D ;

DUFF, P ;

THOMPSON, S ;

BARRETT, K ;

AWE, R ;

CHAPMAN, R ;

LEONARD, S ;

BAINES, L ;

TURNER, P ;

HAWKINS, M ;

MURRAY, H ;

BOWERS, J ;

LANE, C ;

TILSON, H ;

ANDREWS, E ;

SMILEY, L .

JOURNAL OF INFECTIOUS DISEASES, 1992, 166 (06) :1223-1227

[3]

HEINEMANN MH, 1992, AM J MED, V92

[4] PROGRESSION RATES OF CYTOMEGALOVIRUS RETINOPATHY IN GANCICLOVIR-TREATED AND UNTREATED PATIENTS [J].

HOLLAND, GN ;

SHULER, JD .

ARCHIVES OF OPHTHALMOLOGY, 1992, 110 (10) :1435-1442

[5] A CONTROLLED RETROSPECTIVE STUDY OF GANCICLOVIR TREATMENT FOR CYTOMEGALO-VIRUS RETINOPATHY - USE OF A STANDARDIZED SYSTEM FOR THE ASSESSMENT OF DISEASE OUTCOME [J].

HOLLAND, GN ;

BUHLES, WC ;

MASTRE, B ;

KAPLAN, HJ .

ARCHIVES OF OPHTHALMOLOGY, 1989, 107 (12) :1759-1766

[6]

HOOVER D, 1993, NEW ENGL J MED, V26, P1922

[7] PROVISION OF PROGNOSTIC INFORMATION IN IMMUNOCOMPROMISED PATIENTS BY ROUTINE APPLICATION OF THE POLYMERASE CHAIN-REACTION FOR CYTOMEGALOVIRUS [J].

KIDD, IM ;

FOX, JC ;

PILLAY, D ;

CHARMAN, H ;

GRIFFITHS, PD ;

EMERY, VC .

TRANSPLANTATION, 1993, 56 (04) :867-871

[8]

1992, NEW ENGL J MED, V326, P213

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