EXPANDING HORIZONS FOR RECEPTORS COUPLED TO G-PROTEINS - DIVERSITY AND DISEASE

被引：109

作者：

COUGHLIN, SR ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143

来源：

CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 02期

关键词：

D O I：

10.1016/0955-0674(94)90135-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The known repertoire of seven transmembrane domain receptors coupled to G proteins has expanded in several interesting directions. Both loss-of-function and activating mutations have been found at the root of a variety of diseases. More will undoubtedly be uncovered. The diversity of ligands which trigger G protein coupled receptors continues to grow, and with it the variety of known strategies for ligand detection. These and other developments promise continued excitement in this field.

引用

页码：191 / 197

页数：7

共 47 条

[1] G-PROTEIN-COUPLED RECEPTOR GENES AS PROTOONCOGENES - CONSTITUTIVELY ACTIVATING MUTATION OF THE ALPHA-1B-ADRENERGIC RECEPTOR ENHANCES MITOGENESIS AND TUMORIGENICITY [J].

ALLEN, LF ;

LEFKOWITZ, RJ ;

CARON, MG ;

COTECCHIA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (24) :11354-11358

[2] TRANSITION OF BOVINE TRYPSINOGEN TO A TRYPSIN-LIKE STATE UPON STRONG LIGAND-BINDING - REFINED CRYSTAL-STRUCTURES OF BOVINE TRYPSINOGEN-PANCREATIC TRYPSIN-INHIBITOR COMPLEX AND OF ITS TERNARY COMPLEX WITH ILE-VAL AT 1.9 A RESOLUTION [J].

BODE, W ;

SCHWAGER, P ;

HUBER, R .

JOURNAL OF MOLECULAR BIOLOGY, 1978, 118 (01) :99-112

[3] CLONING AND CHARACTERIZATION OF AN EXTRACELLULAR CA2+-SENSING RECEPTOR FROM BOVINE PARATHYROID [J].

BROWN, EM ;

GAMBA, G ;

RICCARDI, D ;

LOMBARDI, M ;

BUTTERS, R ;

KIFOR, O ;

SUN, A ;

HEDIGER, MA ;

LYTTON, J ;

HEBERT, SC .

NATURE, 1993, 366 (6455) :575-580

[4]

CHARO IF, 1994, IN PRESS P NATL ACAD

[5] FAMILIAL GLUCOCORTICOID DEFICIENCY ASSOCIATED WITH POINT MUTATION IN THE ADRENOCORTICOTROPIN RECEPTOR [J].

CLARK, AJL ;

MCLOUGHLIN, L ;

GROSSMAN, A .

LANCET, 1993, 341 (8843) :461-462

[6] HOMEOSTATIC SIGNALS - MARRIAGE OF THE FLYTRAP AND THE SERPENT [J].

CONKLIN, BR ;

BOURNE, HR .

NATURE, 1994, 367 (6458) :22-22

[7]

DOHLMAN HG, 1992, ANNU REV BIOCHEM, V60, P651

[8] THE MOLECULAR EVOLUTION OF NEUROPEPTIDES - PROSPECTS FOR THE 90S [J].

DORES, RM ;

MCDONALD, LK ;

STEVESON, TC ;

SEI, CA .

BRAIN BEHAVIOR AND EVOLUTION, 1990, 36 (2-3) :80-99

[9]

FONG TM, 1992, J BIOL CHEM, V267, P25664

[10] THE EXTRACELLULAR DOMAIN OF THE NEUROKININ-1 RECEPTOR IS REQUIRED FOR HIGH-AFFINITY BINDING OF PEPTIDES [J].

FONG, TM ;

YU, H ;

HUANG, RRC ;

STRADER, CD .

BIOCHEMISTRY, 1992, 31 (47) :11806-11811

← 1 2 3 4 5 →