Effects of recombinant human endostatin on the expression of vascular endothelial growth factor in human gastric cancer cell line MGC-803

被引：19

作者：

Wang, Yu-Bin ^{[1
]}

Liu, Jun-Hong ^{[1
]}

Song, Zong-Min ^{[1
]}

机构：

[1] Liaoning Med Univ, Affiliated Hosp 1, Dept Gen Surg, 5,Sect 3, Guta 121001, Jinzhou, Peoples R China

来源：

BIOMEDICAL REPORTS | 2013年 / 1卷 / 01期

关键词：

recombinant human endostatin; gastric cancer; vascular endothelial growth factor;

D O I：

10.3892/br.2012.3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The present study aimed to explore the effects of recombinant human endostatin, endostar (ES), on the expression of vascular endothelial growth factor (VEGF) in the human gastric cancer cell line MGC-803. The expression of VEGF protein in MGC-803 cells was examined using immunohistochemistry. Subsequent to treatment with various concentrations of ES, the mRNA and VEGF protein expressions were determined in MGC-803 cells. A high level of VEGF protein expression was detected in MGC-803 cells. Subsequent to ES treatment, the mRNA and VEGF protein expressions were significantly decreased in MGC-803 cells (all P<0.05). In conclusion, ES is likely to inhibit the VEGF expression in MGC-803 cells.

引用

页码：77 / 79

页数：3

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